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Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
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Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
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Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
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Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
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相关实验视频

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Brain Imaging Investigation of the Neural Correlates of Emotion Regulation
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悲伤的网络功能障碍 面部表情处理和形态测量在euthymic双相情感障碍中的表情.

Alessandro Miola1, Nicolò Trevisan1, Margherita Salvucci1

  • 1Department of Neuroscience (DNS), University of Padova, Via Giustiniani 5, Padua, Italy.

European archives of psychiatry and clinical neuroscience
|July 27, 2023
PubMed
概括

面部情感识别 (FER) 在双相情感障碍 (BD) 中受损. 双极 I 障碍 (BD-I) 患者在识别悲伤方面表现出明显的缺陷,这与大脑结构的变化有关.

关键词:
双极性障碍是一种双极性障碍.情绪化处理是一种情绪化处理.网络分析 网络分析基于ROI的形态测量方法社会的认知社会认知.基于voxel的形态测量方法

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科学领域:

  • 神经科学是一个神经科学.
  • 精神病学是一个精神病学.
  • 神经成像是一种神经成像.

背景情况:

  • 面部情绪识别 (FER) 对于社交互动至关重要.
  • 双极性障碍 (BD) 与改变的情绪处理有关.
  • 在BD亚型中,FER缺陷的神经支和临床相关性尚不清楚.

研究的目的:

  • 与健康对照组相比,研究双相I型障碍 (BD-I) 和双相II型障碍 (BD-II) 患者的面部情绪识别 (FER) 性能.
  • 探索FER能力,大脑结构 (灰质体积) 和BD中的临床变量之间的关系.
  • 检查FER和相关的神经生物学相关的亚型特定差异.

主要方法:

  • 招募了20名BD-I患者,28名BD-II患者和45名健康对照.
  • 进行面部情绪识别 (FER) 测试.
  • 获得3D-T1权重磁共振成像 (MRI) 来评估皮层-边缘区域的灰色物质体积 (GMV).
  • 利用网络分析来研究FER性能和GMV之间的关系.

主要成果:

  • 与BD-II患者和对照组相比,BD-I患者的整体和悲伤特异性FER表现明显较差.
  • 在BD-I中,受损FER与更长的疾病持续时间和较差的整体功能有关.
  • 在BD-I中,悲伤识别缺陷与更高数量的先前躁狂发作相关.
  • 网络分析显示,在BD-I患者的前端-岛屿-骨区域,GMV相关性减少.
  • 与对照组相比,在BD-I患者中观察到悲伤识别和杏仁体GMV之间的更强的积极关联.

结论:

  • 面部情绪识别 (FER),特别是悲伤,在双极性I型障碍 (BD-I) 中明显受损.
  • 在BD-I中,前端-岛屿-尾区域的网络连接变化和增强的杏仁体-悲伤FER关系可能表明皮质-边缘调制受损.
  • 这些神经生物学变化可能会导致BD-I的情绪失调.
  • 建议对 BD 中 FER 对情绪状态影响进行进一步的纵向研究.