根据四种统计模型在NHANES中对高血压的多种金属的联合暴露
Songfeng Zhao1, Liqiaona Fan2, Yutong Wang1
1Department of Neurosurgery, the Third Xiangya Hospital, Central South University, Hunan, China.
概括
尿道金属如,和锡可能会增加高血压风险,而和则表现出保护作用. 识别关键金属是高血压预防策略的关键.
科学领域:
- 环境健康 环境健康
- 心血管疾病流行病学
- 毒理学 毒理学 毒理学
背景情况:
- 金属暴露越来越多地与高血压有关,但关键的贡献金属仍然不清楚.
- 之前的研究经常检查单一的金属,忽视复杂的混合物对高血压患病率的影响.
研究的目的:
- 评估15种尿道金属对高血压的综合和单独影响.
- 用先进的统计方法识别影响高血压发展的关键金属.
主要方法:
- 从国家健康和营养检查调查 (NHANES) 数据 (2011-2016) 中对5092名参与者的分析.
- 应用加权后勤回归,加权量子素和 (WQS) 回归,基于量子素的g计算 (QGC) 和贝叶斯核机器回归 (BKMR).
主要成果:
- 高血压患病率为37.9%;平均年龄为47.42岁.
- ,和锡是独立的危险因素;,和显示有保护作用.
- ,,,,和锡对于高血压的预测至关重要,金属混合物可能具有积极的综合作用.
结论:
- 尿路,和锡与高血压风险有关.
- 尿中的和与高血压有负面关联.
- 需要进一步的研究来阐明尿路金属暴露在高血压发展中的机制.
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