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Updated: Jul 21, 2025

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
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TREM-2通过促进致病性Th17极化驱动多发性硬化症的发展

Siying Qu1, Shengfeng Hu2, Huiting Xu1

  • 1Center for Infection and Immunity and Guangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, 519000, China.

Neuroscience bulletin
|July 27, 2023
PubMed
概括

在骨髓细胞2 (TREM-2) 上表达的触发受体调节了多发性硬化症 (MS) 中的致病性T助手17 (Th17) 细胞. 抑制CD4+T细胞中TREM-2信号传递可以缓解实验性自身免疫脑膜炎 (EAE) 模型中的疾病活性.

关键词:
实验性的自身免疫性脑膜炎.多发性硬化症是多发性硬化症.T助手 17 帮助 17 帮助触发受体表达在骨髓细胞上 2

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