开放式肺输出策略与传统输出策略相比,在全身麻醉后术后肺部并发症的影响:单中心试点随机对照试验
Julie Girard1,2, Cédrick Zaouter1,2, Alex Moore1,2
1Department of Anesthesiology, Centre hospitalier de l'Université de Montréal, Montreal, QC, Canada.
概括
这项试点研究发现,开放式肺输出术策略可用于减少术后肺部并发症 (PPCs). 进一步的多中心试验是有必要的,以确认其在预防PPC的有效性.
科学领域:
- 麻醉学和重症监护医学
- 呼吸系统医学 呼吸系统医学
背景情况:
- 手术后肺部并发症 (PPC) 是患者发病率的重要原因之一.
- 手术后的骨质疏松症是PPC的一个关键风险因素.
- 目前的输出的策略可能无法充分预防术后的脱.
研究的目的:
- 评估一项试点试验的可行性,将开放式肺排管策略与预防PPCs的传统策略进行比较.
- 探索开放式肺排管策略在减少PPCs中的有效性.
主要方法:
- 进行了一项单中心,双盲随机对照试验.
- 患有PPC中等至高风险的患者被随机分配到开放式肺输出管策略或传统的输出管策略中.
- 主要可行性结果是全球协议的遵守;主要的探索性疗效结果是PPCs.
主要成果:
- 全球协议的遵守率很高 (96%) 并且在各组之间相似.
- 发生了八个PPC:两个在常规组,六个在开放肺组.
- 开放肺部输出管组显示,术后补充氧气的需求减少,肺部通风改善.
结论:
- 试点试验证明了研究开放式肺排气策略的卓越可行性.
- 一个多中心的试点试验,比较开放的肺部输出管与PPC预防的传统策略是可行的.
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