在德国,帕金森病的发病率正在下降
Lotte Dammertz1, Anette Schrag2, Jens Bohlken3
1Department of Epidemiology and Healthcare Atlas, Central Research Institute of Ambulatory Health Care in Germany, Berlin, Germany.
European journal of neurology
|July 27, 2023
概括
在老年德国人中,异常性帕金森病 (IPD) 的发病率从2013年到2019年大幅下降. 在所有年龄组,性别和德国大多数地区都观察到IPD诊断的这种趋势.
科学领域:
- 神经学 神经学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 异常性帕金森病 (IPD) 是一种进展性神经退行性疾病,与衰老密切相关.
- 了解IPD发病率趋势对于公共卫生规划和资源配置至关重要.
研究的目的:
- 分析德国老年人性别和年龄特定的IPD发病率趋势.
- 调查全国IPD诊断率的区域差异.
主要方法:
- 一项全国性的队列研究利用了德国法定医疗保险索赔和处方数据 (约. 87%的人口覆盖率).
- 对50岁及以上的患者进行分析,观察期至少为4年.
- 应用三个不同的病例定义,以确保IPD发病率趋势在2013年至2019年的稳定性.
主要成果:
- 根据年龄和性别标准化的累计IPD发病率从2013年的每10万人中137例下降到2019年的106例.
- 这种下降在男性和女性,所有年龄层和大多数德国地区都得到了一致的观察.
- 在2013年至2019年期间,IPD发病率的相对下降幅度在23%至28%之间,无论使用的病例定义如何.
结论:
- 在德国,在2013年至2019年期间,在Idiopathic帕金森病的年龄和性别标准化发病率的全国性显著下降被确定为2013年至2019年.
- 观察到的趋势在不同的案例定义中保持一致,支持其可靠性.
- 需要进一步的研究来确定导致IPD发病率下降的潜在因素.
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