用耐用心室辅助装置支持的儿童的心肌恢复 - - 一项系统性审查
Sofie Rohde1, Theo M M H de By2, Ad J J C Bogers1
1Department of Cardio-thoracic surgery, Erasmus University Medical Center, Rotterdam, Netherlands.
概括
带有心室辅助装置 (VAD) 的儿科患者可以实现心肌恢复和装置扩展. 即使在长时间的VAD支持和各种潜在条件下,也可能有长期的恢复.
科学领域:
- 儿科心脏病学 儿科心脏病学
- 进行心血管外科手术.
- 再生医学是一种再生医学.
背景情况:
- 一小部分带有心室辅助器件 (VAD) 的儿科患者经历了心肌恢复,从而允许设备的扩展.
- 了解这些儿童的VAD断奶后的临床过程和长期结果至关重要.
研究的目的:
- 系统地审查当前关于儿科患者的临床结果的文献,因为心肌恢复而导致的VAD扩张后.
- 总结由VADs支持的儿童心肌恢复的发生率和长期随访情况.
主要方法:
- 在多个数据库 (Embase,Medline ALL,Web of Science,Cochrane,Google Scholar) 进行了系统的文献搜索,寻找过去十年发表的研究.
- 研究集中在患有持久VAD的儿科患者身上,不包括重叠队列和基于注册表的研究.
主要成果:
- 包括37篇文章,报告总体恢复率为8.7% (81/928).
- 83名患者接受了VAD解释;病因因差异很大. 柏林心脏EXCOR是最常见的设备.
- 报告说,长期康复,非心脏病死亡原因比心脏病死亡原因更频繁.
结论:
- 在VAD支持期间的心肌恢复受到患者,设备,时间和医院相关的复杂因素的影响.
- 在VAD支持后的长期恢复是可以实现的,无论VAD持续时间或病因.
- 需要进一步的研究才能充分理解这种有利的结果.
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