相关实验视频
Updated: Jul 21, 2025

10:42
A Free-breathing fMRI Method to Study Human Olfactory Function
Published on: July 30, 2017
9.7K
探索嗅觉功能障碍作为头部和部癌症中虚弱和术后结果的标记
Leila J Mady1, Emma De Ravin2,3, Varun Vohra1
1Department of Otolaryngology-Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
JAMA otolaryngology-- head & neck surgery
|July 27, 2023
概括
嗅觉功能障碍 (OD) 在头癌 (HNC) 患者中很常见,通常未被发现,并与脆弱性有关. 解决OD可能会改善HNC护理中的脆弱性评估.
科学领域:
- 在瘤学瘤学.
- 老年病的医生 老年病的医生
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 嗅觉功能障碍 (OD) 是脆弱性和死亡率的新兴标志物.
- 脆弱性是头癌 (HNC) 护理的关键因素,但缺乏标准化的评估.
- 需要对HNC患者的OD进行客观评估.
研究的目的:
- 为了确定HNC患者OD的患病率.
- 为了调查过量饮食和虚弱之间的关联.
- 探索在HNC中OD和术后结果之间的关系.
主要方法:
- 51名初级,未接受过治疗的HNC患者的前性队列研究.
- 使用自我报告的VAS和心理物理UPSIT进行嗅觉评估.
- 使用风险分析指数 (RAI) 进行脆弱性评估.
主要成果:
- 近59%的HNC患者客观地测量了OD,尽管正常的自我报告.
- 虚弱的患者的UPSIT分数明显较低.
- 严重的OD与虚弱和更长时间住院的可能性增加有关.
结论:
- 在HNC患者中,OD是普遍存在的,并且往往没有被识别出来.
- 在OD严重程度和脆弱性之间存在剂量依赖的关系.
- 嗅觉评估可以作为HNC脆弱性评估的宝贵工具.
相关概念视频
Olfactory Receptors: Location and Structure
9.4K
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
9.4K
Olfaction
44.5K
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
The olfactory receptors are embedded in the cilia of the...
44.5K
Physiology of Smell and Olfactory Pathway
8.7K
Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
The olfactory...
8.7K
Assessment of Airway, Skin Color, and Use of Accessory Muscles
1.0K
A thorough assessment of respiratory health is paramount in clinical settings to identify and manage respiratory distress and ensure adequate oxygenation. This article elaborates on the critical aspects of respiratory evaluation, including airway assessment, skin color examination, and the observation of accessory muscle use, which are integral to effectively diagnosing and managing patients with respiratory conditions.
Introduction
The initial evaluation of a patient's respiratory system...
Introduction
The initial evaluation of a patient's respiratory system...
1.0K

