遗传和环境对可持续工作生活中的个人差异的贡献-瑞典双胞胎队列研究
Annina Ropponen1,2, Jurgita Narusyte1, Mo Wang1
1Division of Insurance Medicine, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
PloS one
|July 27, 2023
概括
可持续的工作生活受到遗传学和环境的影响. 短期的可持续性更多地依赖于独特的环境因素,而长期的可持续性是由共同和独特的环境影响塑造的,遗传学随着时间的推移起到较小的作用.
科学领域:
- 行为遗传学 行为遗传学
- 职业健康 职业健康 职业健康
- 劳动社会学工作的社会学.
背景情况:
- 遗传学影响了病假和残疾养老金,但其在持续工作生活中的作用不太清楚.
- 关于随着时间的推移保持就业的遗传和环境基础的经验数据很少.
- 了解促进可持续工作生活的因素对于公共卫生和经济生产力至关重要.
研究的目的:
- 调查对短期 (2年) 和长期 (22年) 可持续工作寿命的遗传和环境贡献.
- 区分影响连续就业的病因因素与疾病休假和残疾养老金等中断.
- 利用双胞胎建模,将遗传关系与工作生活轨迹上的共同和独特的环境影响分开.
主要方法:
- 在瑞典一大群同性双胞胎 (n=51,071) 上使用经典双胞胎建模,并使用完整的国家注册数据.
- 分析了有关就业,病假 (SA),残疾养老金 (DP),失业和退休状态的数据.
- 评估了基于zygosity的短期和长期随访期间可持续工作生活中的个人差异.
主要成果:
- 短期可持续工作生活主要由独特的环境因素 (56%) 和遗传因素 (36%) 解释,共享环境最小 (8%).
- 长期可持续的工作生活显示,共同的环境因素 (46%) 和独特的环境因素 (37%) 的影响更大,遗传贡献较小 (18%).
- 这些发现表明影响短期和长期持续就业的病因途径存在差异.
结论:
- 短期的可持续工作生活在很大程度上受到个体特定的环境情况和遗传倾向的影响.
- 长期可持续的工作生活更多地取决于共同的家庭/社会因素和个人环境经验的结合.
- 可持续工作生活的预测因素根据所考虑的时间框架有很大差异,突出了职业发展轨迹的复杂性.
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