带错位与增加的疼痛和增加的突应激激素水平相关 - 一个横截面研究
Marco Brenneis1, Marius Junker1,2, Rebecca Sohn3
1Department of Orthopedics (Friedrichsheim), University Hospital Frankfurt, Goethe University, Frankfurt/Main, Germany.
PloS one
|July 27, 2023
概括
带错位可能会通过缩小关节空间和潜在地激活压力生物标志物来增加膝盖骨关节炎疼痛. 即使是较低的骨倾斜 (PT) 值也与症状恶化和KOA进展有关.
科学领域:
- 整形外科 整形外科 整形外科
- 疼痛管理 疼痛管理
- 生物标志物 生物标志物
背景情况:
- 膝关节骨关节炎 (KOA) 疼痛机制尚未完全理解,因为放射学发现通常与临床症状无关.
- 研究像交感神经系统 (SNS) 活动这样的替代途径对于理解KOA疼痛至关重要.
研究的目的:
- 探索SNS活动升高与KOA严重程度之间的关系.
- 为了确定慢性压力标志物和骨骨不对齐之间的相关性.
- 评估SNS活动,KOA和疼痛感知之间的关联.
主要方法:
- 评估了47名KOA患者,测量了放射性参数 (凯尔格伦-劳伦斯得分,骨倾斜 (PT) 等). ) 的情况.
- 与膝关节特异性 (WOMAC®,KSS©) 和慢性压力调查问卷 (PSQ-20) 相关联的放射性发现.
- 在突液和血清中的量化慢性压力生物标志物.
主要成果:
- 骨倾斜 (PT) 与Caton-Deschamps-Index和中间骨骨关节空间显著相关.
- 不对称的三沟与更高的PT值有关.
- 较低的PT值 (<5°) 与显著更高的膝盖症状得分和增加的突性阿尔多素水平有关.
结论:
- 关节错位,特别是较低的PT值,可能会通过缩小中间关节,导致KOA疼痛增加.
- 这些发现表明,在诊断KOA时需要重新评估标准PT值.
- PT可能会影响突应激生物标志物的释放,可能导致KOA的进展.
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