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相关概念视频

Stem Cell Culture01:17

Stem Cell Culture

5.2K
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Embryonic Stem Cells00:57

Embryonic Stem Cells

3.6K
Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
3.6K
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.1K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.1K
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

4.2K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
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相关实验视频

Updated: Jul 21, 2025

In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells
05:32

In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells

Published on: February 16, 2024

482

在体内进行干细胞工程的第一步

Samuele Ferrari1, Luigi Naldini1,2

  • 1San Raffaele Telethon Institute for Gene Therapy, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele, Milan, Italy.

Science (New York, N.Y.)
|July 27, 2023
PubMed
概括

传递信使RNA (mRNA) 具有彻底改变造血干细胞基因疗法的潜力. 这种创新方法可能会显著改变影响血干细胞的遗传疾病的当前治疗模式.

科学领域:

  • * 血液学和基因治疗
  • * 分子生物学与药物输送

背景情况:

  • 血造干细胞 (HSC) 基因疗法是治疗遗传性血液疾病的一个有前途的方法.
  • 目前的基因治疗方法在效率和安全性方面面临挑战.

研究的目的:

  • * 探索传递 RNA (mRNA) 在 HSC 中的基因传递潜力.
  • * 评估mRNA作为HSC基因疗法的转化方法.

主要方法:

  • * 研究基于mRNA的HSC传递系统.
  • * 评估这种新型基因转移方法的有效性和可行性.

主要成果:

  • * mRNA输送显示有可能修改HSC基因治疗.
  • * 这种方法可以克服现有的基因治疗技术的局限性.

结论:

  • * 基于mRNA的输送代表了HSC基因治疗的范式转变.
  • * 需要进一步的研究,以充分实现mRNA在该领域的治疗潜力.

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