在患有伯基特淋巴瘤的患者中,临床结果和医疗保健利用
P Connor Johnson1,2, Netana H Markovitz2,3, Alisha Yi1,2
1Department of Medicine, Division of Hematology & Oncology, Massachusetts General Hospital, Boston, MA.
JCO oncology practice
|July 27, 2023
概括
患有伯基特淋巴瘤的成年人,尤其是老年人,在治疗期间面临住院和重症监护室 (ICU) 住院的高率. 这凸显了需要更好的支持性护理,以改善这些侵略性B细胞淋巴瘤患者的治疗结果.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 临床结果研究研究
背景情况:
- 伯基特淋巴瘤是一种侵略性的B细胞淋巴瘤,需要密集治疗.
- 对伯基特淋巴瘤的密集治疗存在严重毒性的风险.
- 关于伯基特淋巴瘤患者,特别是老年人的临床结果和医疗利用情况的数据有限.
研究的目的:
- 描述患有伯基特淋巴瘤的40岁及以上成年人的临床结果和医疗利用情况.
- 在治疗伯基特淋巴瘤期间,确定与非计划住院和重症监护室 (ICU) 住院相关的因素.
主要方法:
- 在1999年至2020年期间治疗的97名Burkitt淋巴瘤成年患者 (≥40岁) 的回顾性分析.
- 从电子健康记录中抽取的数据包括患者特征,临床结果和医疗保健利用率 (无计划住院,ICU入院).
- 使用单变量后勤回归来检查与非计划住院和ICU入院相关的因素.
主要成果:
- 45.8%的患者经历了无计划住院治疗,23.2%的患者在治疗期间接受了ICU治疗.
- 老年人 (≥70岁) 的非计划住院率高 (36.8%) 和ICU入院率高 (29.0%).
- 高龄,并发症和低albuminemia与增加ICU入院风险有关;8.7%的患者在治疗期间死亡,所有患者年龄在70岁以上.
结论:
- 成年伯基特淋巴瘤患者经历了大量的意外住院和ICU入院.
- 患有伯基特淋巴瘤的老年人患有ICU入院和与治疗相关的死亡风险特别高.
- 急需支持性护理干预措施,以改善伯基特淋巴瘤患者的治疗结果和医疗保健利用率.
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