严重急性营养不良的儿童有很高的骨质再吸收率:一个横截面比较研究
Sreetama Das1, Rajesh Kumar Meena1, Dheeraj Shah1
1Department of Pediatrics, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India, 110095.
Nutrition research (New York, N.Y.)
|July 27, 2023
概括
患有严重急性营养不良 (SAM) 的儿童表现出骨吸收增加,表明骨健康受损. 这项研究测量了SAM儿童的骨循环标志物,揭示了与营养良好同龄人相比,骨复苏率更高.
科学领域:
- 儿童营养学 儿童营养学
- 骨的新陈代谢 骨的新陈代谢
- 公共卫生 公共卫生
背景情况:
- 5岁以下儿童严重急性营养不良 (SAM) 是一个重要的全球健康问题.
- 由于适应性反应,SAM中可能会发生骨健康的微妙变化.
- 骨循环标记可以帮助评估骨形成和再吸收率.
研究的目的:
- 评估SAM儿童的骨循环标志物,特别是血清骨质卡尔辛和血清酸耐药酸酸酶-5b (TRAP-5b).
- 为了比较SAM儿童与正常营养状况儿童之间的骨转化标志物.
- 研究SAM中骨转化标记物,和维生素D水平之间的关系.
主要方法:
- 一项涉及30名SAM儿童 (6-59个月) 和30名年龄和性别匹配的健康儿童的横截式比较研究.
- 测量血清骨质卡尔辛和血清TRAP-5b度.
- 评估低血症和维生素D缺乏的流行率.
主要成果:
- 在患有SAM的儿童中,血清TRAP-5b度显著更高 (22.6 [15.3]对11.3 [9.6],P=.009),表明骨再吸收增加.
- 血清骨质卡尔辛水平在两组之间是可比的 (40.6 [17.9] 对比 36.0 [12.5],P=.344).
- 在SAM儿童中观察到较高频率的低血症和维生素D缺乏 (P < .05).
结论:
- 与正常营养状况相比,SAM儿童表现出较高的骨质再吸收率.
- 在患有严重急性营养不良的儿童中,表明骨健康受到损害.
- 对SAM骨健康干预措施的进一步研究是有必要的.
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