大脑转移在 de novo 第四期乳腺癌中的转移
Yaning He1, Yingbo Shao1, Qi Chen1
1Department of Breast Oncology, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou, China; Department of Breast Oncology, Henan Provincial People's Hospital, Henan University People's Hospital, Zhengzhou, China.
Breast (Edinburgh, Scotland)
|July 27, 2023
概括
在新发乳腺癌第四阶段的大脑转移 (BM) 与亚型和转移部位的数量有关. 了解这些因素可以改善诊断策略和患者对这种具有挑战性的疾病的治疗结果.
科学领域:
- 在瘤学瘤学.
- 临床研究 临床研究
- 流行病学 流行病学
背景情况:
- 大脑转移 (BM) 是 de novo 第四阶段乳腺癌的一个重大临床挑战,现有数据有限.
- 了解BM的发病率和预后因素对于临床决策和患者管理至关重要.
研究的目的:
- 为了调查发病率,并确定脑转移的预测因子,在患者 de novo 第四期乳腺癌.
- 在这个患者群体中分析与整体存活 (OS) 相关的因素.
主要方法:
- 来自2015-2019年SEER数据库的1366名乳腺癌和乳腺癌新发4期患者的回顾性分析.
- 多变量后勤和考克斯回归模型被用来确定BM预测因素和死亡率因素.
- 卡普兰-梅尔和日志等级测试评估了整体存活率.
主要成果:
- 乳腺癌IV期新发的乳腺癌的发病率为8.38%,HR-HER2+ (12.95%) 和HR-HER2- (13.40%) 亚型的发病率更高.
- 瘤发生率随着外转移部位数量的增加而增加.
- 平均生存期为12.0个月,根据亚型不同 (HR+ HER2+最长为19.0个月;HR-HER2-最短为7.0个月).
结论:
- 乳腺癌的发病率和预后在IV期乳腺癌中受到瘤亚型和转移性负担的显著影响.
- 这些研究结果支持开发有针对性的诊断和查策略,特别是在大脑参与方面.
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