父母心理病理和后代大脑结构之间的关联的特异性
Matthew Mattoni1, Helene J Hopman2, Adefunke Dadematthews3
1Department of Psychology and Neuroscience, Temple University, Philadelphia, PA, USA.
Psychiatry research. Neuroimaging
|July 27, 2023
概括
父母的精神病理可能会影响孩子的大脑结构,特别是杏仁体和条纹体积. 伴随性疾病或多重疾病似乎会减轻儿童的这些影响,这表明当父母有并发疾病时,体积较小.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 精神病学是一个精神病学.
背景情况:
- 父母的精神病理与儿童皮层下大脑体积的变化有关.
- 父母共患病对儿童大脑结构的影响仍未得到充分探索.
研究的目的:
- 调查儿童皮质下大脑结构的改变是否与父母的抑郁症,焦虑症,躁狂症或物质使用障碍有关.
- 确定这些变化是否受到父母多种疾病史 (并发症) 的影响.
主要方法:
- 从ABCD研究中分析了6,581名没有精神疾病史的儿童 (年龄为9-10岁).
- 检查家长心理病理类型和儿童皮质下大脑体积 (杏仁体,纹体) 之间的相互作用.
- 对内体积和其他父母精神病理形式的统计控制,不包括儿童精神病理.
主要成果:
- 显著的相互作用表明,父母的并发症缓解了抑郁症,焦虑症和药物使用史对杏仁体和条形状体的影响.
- 这些相互作用表明,父母报告伴随性疾病的儿童的体积较小.
- 效果大小很小,在多次比较纠正后,没有任何关联仍然显著.
结论:
- 心理病理学的家族风险在9-10岁的孩子中显示出与后代大脑结构的适度关联.
- 杏仁体和条形状区域都参与了这些关联.
- 父母共同病态精神病理病史似乎能够缓解这些关系,这表明对儿童神经发育的复杂家族影响.
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