危急病患者:甲状腺功能障碍的组织病理证据
Dipti Saha1, Saurabh Chattopadhyay2, Sayak Sovan Dutta2
1Nilratan Sircar Medical College and Hospital, 138 Acharya Jagadish Chandra Bose Road, Kolkata, West Bengal 700014, India.
Journal of critical care
|July 27, 2023
概括
危急疾病会导致甲状腺严重受损,导致非甲状腺疾病 (NTI). 组织病理学研究揭示了严重病患者的甲状腺结构扭曲和细胞变化.
科学领域:
- 内分泌学 在内分泌学.
- 病理学 病理学 病理学
- 关键护理医学 关键护理医学
背景情况:
- 危急疾病涉及严重的代谢压力和全身炎症.
- 非甲状腺疾病 (NTI) 经常在重症患者中观察到.
- NTI的细胞形态学基础需要进一步研究.
研究的目的:
- 为了研究因严重疾病而死亡的患者甲状腺的组织病理变化.
- 阐明在重症监护机构中与NTI相关的细胞形态变化.
主要方法:
- 来自58名重症患者的尸检甲状腺样本被检查.
- 病例包括烧伤,创伤性脑损伤和脑中风.
- 标准的血素和素染色和光显微镜被使用.
主要成果:
- 在58名患者中,有21名患者 (36%) 发现甲状腺正常.
- 大多数病例显示出显著的组织病理学变化.
- 关键发现包括甲状腺毛囊架构的扭曲,单核细胞透,甲状腺球蛋白凝聚和毛囊疲劳.
结论:
- 危急疾病会对甲状腺产生代谢破坏性的影响,与低T3综合征相一致.
- 与创伤性脑损伤相比,甲状腺变化在烧伤和脑中风中更加明显.
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