在生活在社区的人群中,高级大脑年龄,身体和认知障碍综合
Chen-Yuan Kuo1, Pei-Lin Lee1, Li-Ning Peng2
1Center for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan; Institute of Neuroscience, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Neurobiology of aging
|July 27, 2023
概括
先进的大脑衰老,通过大脑年龄差距来表明,与老年人身体和认知能力的综合下降有关. 这表明生理认知衰退综合征可能反映了加速的生物衰老.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 医疗成像医学成像
背景情况:
- 加速的大脑衰老在老年人群中越来越令人担忧.
- 了解其与功能衰退的联系对于公共卫生至关重要.
- 之前的研究已经探讨了与各种健康结果有关的大脑年龄.
研究的目的:
- 为了研究大脑的生物年龄与与年龄相关的身体和认知功能衰退之间的联系.
- 分析不同功能衰退群体中的大脑年龄差距 (BAG):运动障碍没有残疾 (MIND),认知障碍没有痴呆症 (CIND) 和生理认知衰退综合征 (PCDS).
主要方法:
- 开发了一个大脑年龄预测模型,使用来自1482名健康个体 (18-92岁) 的MRI扫描的灰质特征.
- 大脑年龄差距 (BAG) 被计算为预测年龄和时间年龄之间的差异.
- 在1193名居住在社区的老年人 (≥50岁) 的单独队列中分析了BAG,分为强壮,CIND,MIND和PCDS组.
主要成果:
- 与强壮 (-0.49 ± 9.27),CIND (0.47 ± 9.16) 和MIND (0.36 ± 9.69) 组相比,患有PCDS的参与者表现出明显更大的BAG (2.99 ± 8.97) .
- 这些差异在所有比较中都具有统计学意义 (p < 0.05).
- 这些发现表明,大脑晚期衰老与身体和认知能力的综合衰退之间存在明显的关联.
结论:
- 晚期大脑衰老在老年人同时出现的身体和认知衰退的病理生理学中发挥着作用.
- 身体认知衰退综合征 (PCDS) 可能代表社区居住的老年人加速生物衰老的临床表型.
- 这些发现强调了考虑大脑年龄作为功能衰退和健康衰老的生物标志物的重要性.
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