住院治疗粉样蛋白相关心力衰竭的不良结果
Sandeep Appunni1, Muni Rubens2, Venkataraghavan Ramamoorthy3
1Government Medical College, Kozhikode, Kerala, India.
The American journal of cardiology
|July 27, 2023
概括
晶氨基氨基酸心肌病变 (ATTR-CM) 是心力衰竭 (HF) 的一个被诊断不足的原因. 由于ATTR-CM而住院的病例正在增加,并且与更糟糕的结果有关,包括更高的死亡率和更长的住院时间.
科学领域:
- 心脏病学 心脏病学
- 内部医学 内部医学
- 遗传学 遗传学 是一个
背景情况:
- 晶胺氨基酸心肌病变 (ATTR-CM) 是日益公认的心力衰竭 (HF) 的原因.
- 由于ATTR-CM的诊断往往不足,导致治疗延迟,患者的治疗结果可能更差.
研究的目的:
- 分析因粉样蛋白相关心力衰竭 (HF) 住院的不良结果.
- 为了确定与粉样蛋白相关的HF住院治疗的发病率和患者人口统计的趋势.
主要方法:
- 从2016年到2019年对国家住院样本 (NIS) 数据库的回顾性分析.
- 纳入标准:年龄在41岁或以上,因HF而入院的患者.
- 用ICD-10-CM代码识别与粉样蛋白相关的HF,用于粉样蛋白症.
主要成果:
- 从2016年到2019年,有4,705,274例HF住院治疗;16955例 (0.4%) 是因为粉样性心肌病.
- 与粉样蛋白相关的HF住院病例增加了76.9% (2016年为0.26%,2019年为0.46%).
- 与粉样蛋白相关的HF在老年,男性和黑人患者中更为常见,在住院死亡率 (OR 1.29) 较高,住院时间长 (OR 1.61) 和血管压缩剂使用 (OR 1.59) 的几率更高.
结论:
- 与粉样蛋白相关的HF住院病例正在显著增加,并与不良结果相关.
- 这些住院病例不成比例地影响着老年,男性和黑人人口.
- 早期识别和迅速管理ATTR-CM对于改善患者的治疗结果至关重要.
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