感官皮层中的VIP内神经元编码感官和动作信号,但不是直接的奖励信号
Deepa L Ramamurthy1, Andrew Chen1, Jiayu Zhou1
1Department of Molecular & Cell Biology and Helen Wills Neuroscience Institute, UC Berkeley, Berkeley, CA 94720-3200, USA.
感官皮层中的血管活性肠 (VIP) 细胞在目标定向任务期间对胡须刺激和动作做出反应. 这些神经元不会直接信号强化,但可能编码与运动行为相关的奖励期望.
科学领域:
- 神经科学是一个神经科学.
- 感官处理 感官处理
- 皮层电路中的皮层电路.
背景情况:
- 感官皮层中的血管活性肠 (VIP) 内神经元影响基于兴奋和行为的感官处理.
- 它们在以目标为导向,非探索性行为中的作用,特别是关于感官线索,行为和强化方面的作用,仍然不太了解.
研究的目的:
- 在一个目标导向的任务期间,调查胡须体感皮质 (S1) 中L2/3 VIP神经元的激活模式.
- 在VIP细胞中区分感官唤起,行动相关和奖励相关的活动.
主要方法:
- 训练小鼠进行Go/NoGo胡须触摸检测任务,并设置延迟期.
- 两光子成像用于测量S1 L2/3 VIP神经元在行为过程中的神经活动 (ΔF/F).
主要成果:
- 在初学者和专家小鼠中,VIP细胞被胡须刺激和动作激活.
- VIP细胞的反应显示了对胡须刺激的体质调,与广泛的相关信号不同.
- 在专家小鼠中,奖励递送抑制了与相关的VIP反应,抑制强度与奖励大小相关.
结论:
- 贵宾细胞是通过局部感官输入和目标导向的运动动作来激活的,而不是直接通过强化.
- VIP神经元活动可能反映出与特定运动行为相关的奖励的期望.
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