用肠道微生物群为导向调节的食品和药物设计:当前的实验格局和未来的创新
Xiaoxiang Gao1, Jianxin Zhao1, Wei Chen2
1State Key Laboratory of Food Science and Resources, Jiangnan University, Jiangnan University, Wuxi, Jiangsu 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China.
Pharmacological research
|July 27, 2023
概括
微生物群导向的饮食和药物通过专注于特定的微生物来提供有针对性的健康改善. 本综述探讨了发现这些有针对性的干预措施的方法,旨在提高精准医学.
科学领域:
- 微生物组研究的研究.
- 精准医学是一门精准的医学.
- 肠道健康 肠道健康
背景情况:
- 当前的饮食和药物通过肠道微生物群影响宿主健康,但往往缺乏有针对性的调节.
- 非向的方法可以降低治疗和补充剂的有效性.
- 以微生物群为导向的干预措施旨在选择性地调节特定的微生物,以获得治疗效益.
研究的目的:
- 审查和总结最近发现微生物群导向食品和药物的方法.
- 讨论当前方法的实施,解释和局限性.
- 提出开发微生物群导向疗法的框架,以推进精准医学.
主要方法:
- 来自各种数据库的30项研究的系统审查.
- 基于实验模型的方法分类:体内,体外和生物信息学预测.
- 对现有的微生物组操纵技术的分析.
主要成果:
- 确定了四个主要的方法组,用于探索微生物群导向干预措施.
- 评估了不同实验和预测方法的优缺点.
- 突出了当前的景观和现场挑战.
结论:
- 需要普遍适用的方法来发现微生物群导向的食物和药物.
- 综合各种方法的综合框架可以指导未来的研究.
- 微生物群指导的策略对准确医学的未来具有重大前景.
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