在中年和老年人中,高自杀风险的积极价值系统功能和无情感
Jennifer N Bress1, Elizabeth Arslanoglou1, Samprit Banerjee2
1Weill Cornell Institute of Geriatric Psychiatry, Department of Psychiatry, Weill Cornell Medicine, White Plains, New York.
面临自杀风险的老年人表现出可靠的奖励积极性 (RewP) 大脑信号. 较小的RewP与更大的疲劳,无情感和抑郁症状有关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 老年学是一门学科.
背景情况:
- 积极价值系统在晚年抑郁症和自杀风险中被破坏.
- 奖励积极性 (RewP) 衡量积极的价值系统功能,与年轻人群中的抑郁和无情相关.
- 在中年和年长的自杀风险较高的成年人中,RewP的可靠性和临床相关性尚不清楚.
研究的目的:
- 为了确定是否可靠的RewP信号可以引起中年和老年人自杀的高风险.
- 在这个人群中调查 RewP 信号与临床症状之间的关联.
主要方法:
- 一个标准的博任务被用来引起31名中年和老年人因自杀念头或行为而住院的RewP.
- 记录了对货币收益和损失的电皮质反应.
- 评估了RewP的内部可靠性和反负面性 (FN),以及剩余差异得分.
主要成果:
- 观察到对货币收益与损失的显著电皮质反应,表明可靠的 RewP.
- 对于RewP和FN的内部可靠性很好或很好;差异指标显示可接受的可靠性.
- 较小的残留RewP,控制FN,与更严重的疲劳相关,这是食欲无味的指标.
结论:
- 可靠的 RewP 信号可以在中年和年长的自杀风险较高的成年人中引起.
- 减少的RewP,独立于反消极性,与这个人口群中的食欲无味有关.
- 这些发现支持未来对晚年抑郁症和自杀风险的积极价值系统功能的研究.
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