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基因型4的HEV感染触发了急性胰腺炎的开始和发展
1Department of Clinical Laboratory, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, 242 Guangji Road, Suzhou, 215008, Jiangsu, China.
Microbes and infection
|July 27, 2023
概括
肝炎E病毒 (HEV) 感染与急性胰腺炎 (AP) 有关. 较高的HEV率和病毒载荷与增加的AP严重程度和较差的结果相关,影响疾病的发展和预后.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 病毒学 病毒学
- 胃肠病学 胃肠病学
背景情况:
- 肝炎E病毒 (HEV) 感染与急性胰腺炎 (AP) 之间的关联需要进一步阐明.
- 高肝病毒是一个重大的全球健康问题,其肝外表现越来越被认可.
研究的目的:
- 研究HEV感染在急性胰腺炎的发生,发展和预后中的作用.
- 评估HEV感染率及其对AP严重程度和患者结局的影响.
主要方法:
- 在1000名AP患者和1000名健康对照 (HC) 中对HEV感染标志物 (抗HEV IgG,IgM,HEV RNA) 的比较分析.
- 评估与HEV感染状况相关的AP严重程度和结果.
- 在 rhesus macaque 模型中评估 HEV 诱导的胰腺损伤.
主要成果:
- 与HC相比,AP患者的抗HEVIgG,IgM和HEVRNA水平显著更高.
- 增加的HEV感染患病率与更高的AP严重程度相关.
- 确定HEV感染是AP的独立风险因素,高病毒标位预测了长时间的恢复和复发的AP.
- 在 rhesus 的胰腺中HEV复制导致结构损伤,炎症和高血压.
- 与单独的AP相比,患有AP和伴随着的HEV感染 (AP + AHE) 的患者表现出较高的严重AP百分比.
结论:
- HEV感染在急性胰腺炎的发病,进展和预后方面发挥着重要作用.
- HEV感染是影响AP结果的关键独立风险因素.
- 这些发现支持HEV作为AP的潜在病因因因子,需要在临床诊断和管理中考虑.
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