在哥伦比亚三个采矿人口中,微核的频率和化学混合物的暴露
Karina Pastor-Sierra1, Lyda Espitia-Pérez2, Pedro Espitia-Pérez2
1Grupo de Investigación Biomédica y Biología Molecular, Universidad del Sinú, Montería, Córdoba, Colombia; Programa de doctorado en Salud Pública, Universidad El Bosque, Bogotá, Colombia.
The Science of the total environment
|July 27, 2023
概括
哥伦比亚的采矿活动使人口暴露在化学混合物中,增加了染色体不稳定性 (CIN). (Se) 始终与整个采矿场的CIN升高相关,突出了暴露社区的风险.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 职业健康 职业健康 职业健康
背景情况:
- 哥伦比亚矿业的增长产生了复杂的化学混合物.
- 接触这些混合物会影响矿山项目附近的人口.
- 染色体不稳定性 (CIN) 越来越多地与暴露在化学物质中的疾病有关.
研究的目的:
- 研究复杂化学混合物暴露对染色体不稳定性 (CIN) 的影响.
- 在哥伦比亚采矿区和参考地点的个人中进行生物监测.
- 在不同的采矿环境中识别与CIN相关的特定元素.
主要方法:
- 在四个不同的领域 (大规模,小规模,工艺和参考) 进行了407名健康个体的生物监测.
- 使用ICP-MS分析头发样本进行多元体暴露评估.
- 使用细胞动力学阻断微核 (MNBN) 技术评估CIN.
主要成果:
- 与参考地点相比,采矿区的化学元素暴露率明显高于采矿区.
- 在蒙特利巴诺,MNBN频率升高与Se,Hg,Mn,Pb和Mg有关.
- 在Nechi,Cr,Ni,Hg,Se和Mg是MNBN的主要贡献者;在Aranzazu,Hg和Ni.
- (Se) 始终与所有活跃的采矿区的MNBN增加相关.
结论:
- 从采矿中暴露于复杂的化学混合物与染色体不稳定性增加有关.
- 具体的元素配置文件与MNBN频率相关,这取决于采矿规模和位置.
- 对CIN的生物监测对于评估矿业影响社区的健康风险至关重要.
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