循环中介素-39作为一种潜在的风湿性关节炎诊断的生物标志物
Lina Ying1, Luping Gong2, Sicen Meng2
1Department of Clinical Laboratory, Ningbo No.6 Hospital Affiliated to Ningbo University, Ningbo 315040, China; Zhejiang Key Laboratory of Pathophysiology, Ningbo University Health Science Center, Ningbo 315211, China.
Clinical biochemistry
|July 27, 2023
概括
在类风湿性关节炎 (RA) 患者中,高水平的干白素-39 (IL-39) 表明IL-39可能是诊断这种自身免疫性疾病的有价值生物标志物.
科学领域:
- 免疫学 免疫学 免疫学
- 类风湿病学 类风湿病学
- 生物化学 生物化学
背景情况:
- 细胞因子网络不平衡与类风湿性关节炎 (RA) 病变发生有关.
- 介素 (IL) -12家族,包括新型IL-39,在自身免疫性疾病中起作用.
- 在RA中IL-39的特定作用在很大程度上仍未确定.
研究的目的:
- 在RA患者的血清中研究IL-39的表达.
- 为了确定IL-39水平与RA疾病活性之间的关系.
主要方法:
- 招募了46名RA患者和35名健康对照.
- 使用酶相关免疫吸收试验 (ELISA) 测量了血清IL-39度.
- 使用28关节计数和C反应蛋白 (CRP) 评估疾病活性.
- 使用皮尔森相关性测试分析了IL-39和临床指标之间的相关性.
主要成果:
- 与健康对照组相比,RA患者的血清IL-39水平显著升高 (p < 0.0001).
- IL-39水平与风湿性因素 (RF),红细胞沉积率 (ESR) 和IgM有正相关性.
- 接收器操作特征 (ROC) 曲线分析表明IL-39对RA的诊断值 (p < 0.0001).
结论:
- 在RA患者中血清IL-39的增加表明它参与了疾病的发病.
- IL-39与RA活性的关键临床指标具有积极的相关性.
- IL-39显示出作为类风湿性关节炎诊断生物标志物的潜力.
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