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在帕金森病中,语音的可理解性依赖于解剖学上分离的亚thalamic beta 振荡
Federica Avantaggiato1, AmirAli Farokhniaee2, Andrea Bandini3
1Department of Neurology, University Hospital of Würzburg and Julius Maximilian University of Würzburg, Josef-Schneider-Straße 11, 97080 Würzburg, Germany.
Neurobiology of disease
|July 27, 2023
概括
帕金森病的语音障碍可以通过了解亚体内核 (STN) 活动来改善. 左和右STN中的特定神经频率与语音产生和可理解性相关,指导新的深度大脑刺激策略.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 语音科学 语言科学
背景情况:
- 语音障碍是帕金森病的一个常见且具有挑战性的症状.
- 目前的治疗方法,包括下丘脑核深度大脑刺激 (STN-DBS),提供不一致的语音改进,有时会恶化沟通.
研究的目的:
- 为了研究神经活动在脑下细胞核和语音的生产/可理解性之间的关系.
- 了解STN神经活动在言语运动控制中的具体作用.
主要方法:
- 在9名帕金森病患者的双边下丘脑核局部场潜力 (LFP) 记录在公开阅读过程中.
- 与临床评估和语音可理解性的客观测量相关联的LFP光谱特征.
主要成果:
- 左STN中的β-低频 (12-20 Hz) 功率增加与公开读数有关.
- 增强的语音可理解性与右STN中的β高频率 (20-30 Hz) 功率正相关.
结论:
- 在STN中,不同的频段和侧面化对语音运动执行和可理解性有不同的贡献.
- 这种理解可以为开发适应性STN-DBS策略提供信息,以优化帕金森病中的语音功能.
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