周围手术触发了巨细胞的激活:专注于神经炎症
Piplu Bhuiyan1, Zhaochu Sun1, Yinan Chen1
1Department of Anesthesiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu, People's Republic of China.
Behavioural brain research
|July 27, 2023
概括
外围手术通过巨细胞 (MCs) 和免疫信号触发大脑炎症,可能导致认知缺陷. 了解这些神经炎症通路为治疗提供了新的治疗点.
科学领域:
- 神经免疫学 神经免疫学
- 外科手术炎症 在外科手术炎症.
- 认知障碍 认知障碍是一种认知障碍.
背景情况:
- 外围手术诱导系统性炎症反应,影响大脑.
- 周围炎症和大脑之间的神经免疫相互作用会导致认知障碍.
- 巨细胞 (MCs) 是手术创伤后的神经炎症级联中的关键参与者.
研究的目的:
- 为了阐明外围手术后巨细胞介导的神经炎症的机制.
- 确定潜在的治疗点,以减轻手术诱导的炎症级联和认知功能障碍.
主要方法:
- 对外围手术后神经炎症的科学证据的审查.
- 对巨细胞激活和媒介释放的分析.
- 检查下丘脑-垂体-上腺 (HPA) 轴和皮质激素释放激素 (CRH) 的作用.
主要成果:
- 周围手术激活大脑居住的巨细胞,释放炎症介导体,如组胺和酶.
- 这些介质破坏血脑屏障 (BBB),并激活先天性免疫细胞 (微质,星球细胞).
- 手术压力和CRH可以进一步激活巨细胞,损害突触可塑性.
结论:
- 乳腺细胞是外周手术后神经炎症反应的核心.
- 向巨细胞激活和相关的炎症调解剂是预防手术引起的认知障碍的有希望的治疗策略.
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