规范型建模分析显示,在早期和中期到晚期的第一次主要抑郁症发作时,体体体积的变化
1Key Laboratory of Cognition and Personality, Faculty of Psychology, Southwest University, Chongqing, China; Faculty of Medicine and Health Sciences, Department of Head and Skin, Ghent Experimental Psychiatry (GHEP) lab, Ghent University, Ghent, Belgium.
Journal of affective disorders
|July 27, 2023
概括
大型抑郁症 (MDD) 可以改变体体 (CC) 的体积,特别是在早期发病的情况下. 早期干预对于管理这些大脑变化在第一个MDD患者的管理至关重要.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 神经成像是一种神经成像.
背景情况:
- 大型抑郁症 (MDD) 被广泛认为会影响大脑结构,如体 (CC).
- 现有的研究受限于小样本大小,并且缺乏关于第一集MDD中CC体积变化的清晰度.
- 在最初的抑郁情节中存在CC体积变化的存在仍然不清楚.
研究的目的:
- 为了研究第一期重度抑郁症 (MDD) 患者的体 (CC) 体积差异.
- 为了比较早期发病和中期到晚期发病的第一期MDD患者和健康对照之间的CC (子) 量.
- 为了探索抑郁症严重程度和CC (子) 量之间的关系,在第一集的MDD.
主要方法:
- 利用REST元MDD数据库,比较369名首发MDD患者与490名从未患过抑郁症的人.
- 采用具有Z分数的规范性神经解剖学建模来评估CC (子) 卷中的个体变异性.
- 根据年龄和性别对患者和对照进行了匹配,分析了早期发病 (≤44岁) 和中晚发病 (≥45岁) 的MDD亚组.
主要成果:
- 与健康规范相比,第一期MDD患者的CC体积 (整个CC和身体) 减少.
- 中期至晚期首发MDD患者也表现出降低的CC体积.
- 在早期发病的第一期MDD中,更大的抑郁严重程度与增加的CC体积 (整个CC,身体和脏) 相相关.
结论:
- 在早期发病和中期到晚期发病的第一期MDD之间观察到CC (子) 量差异.
- 早期发病的MDD中抑郁症的严重程度可能与神经白质活性作为应对压力的反应有关.
- 由于潜在的白质变化,建议对早期发病的MDD进行及时的临床干预.
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