在脊髓损伤之前和之后,脊髓控制运动
Simon M Danner1, Courtney T Shepard2, Casey Hainline3
1Department of Neurobiology and Anatomy, College of Medicine, Drexel University, Philadelphia, PA, USA.
Experimental neurology
|July 27, 2023
概括
研究老鼠跨速运动的研究揭示了胸脊髓损伤如何损害协调. 恢复允许高速移动,但会改变步态和肢体使用,突出隐藏电路功能障碍.
科学领域:
- 神经科学是一个神经科学.
- 机车运动 机车运动 机车运动
- 脊髓损伤研究 脊髓损伤研究
背景情况:
- 胸脊髓损伤会影响前肢和后肢运动协调所必需的长长的自身脊髓神经元.
- 运动恢复研究通常使用有限的速度范围,可能掩盖潜在的神经电路缺陷.
研究的目的:
- 为了研究大鼠在胸部半截切或伤之前和之后的各种速度的地面运动.
- 揭示速度变化如何揭示脊柱电路功能障碍和伤害后恢复模式.
主要方法:
- 训练老鼠在长距离上以各种速度移动.
- 在受伤前和从胸部半截切或伤中恢复后分析了运动运动.
- 评估了步行模式,速度和四肢间协调.
主要成果:
- 完整的老鼠表现出了一系列取决于速度的步态,包括交替和非交替的模式.
- 半截肢损伤导致运动恢复,但失去了高速步行和改变了肢偏好.
- 伤损伤导致最大速度降低,失去了非交替步态,由于前后合受损而导致新的交替步态.
结论:
- 研究整个速度范围内的运动,揭示了脊柱运动控制和伤害后恢复的隐藏方面.
- 脊髓损伤显著改变了步行策略和肢体间协调,以取决于速度的方式.
- 脊髓神经元的完整性对于复杂的高速运动至关重要,但即使在它们被破坏后,也可以恢复一些协调.
相关概念视频
Indirect Motor Pathways
1.6K
The indirect motor or extrapyramidal pathways originate in the brainstem, the lower portion of the brain that connects it to the spinal cord. They consist of several distinct tracts, each with specialized functions. The four main tracts of the indirect motor pathways are the vestibulospinal tract, the reticulospinal tract, the tectospinal tract, and the rubrospinal tract.
The vestibulospinal tract originates in the vestibular nuclei of the brainstem. The vestibular system detects changes in...
The vestibulospinal tract originates in the vestibular nuclei of the brainstem. The vestibular system detects changes in...
1.6K
Spinal Cord: Cross-sectional Anatomy
2.0K
The cross-sectional anatomy of the spinal cord offers a detailed view of its complex structure and function within the central nervous system. At the core of the spinal cord lies the gray matter, characterized by its butterfly or "H"-shaped appearance in cross-section. This central region is enveloped by white matter, with the overall structure divided into symmetrical halves by the dorsal median sulcus and the ventral median fissure.
Gray Matter and its Components
Central to the gray matter is...
Gray Matter and its Components
Central to the gray matter is...
2.0K
Hierarchy of Motor Control
2.9K
The hierarchy of motor control refers to the different levels of organization and processing involved in controlling movement in the body. These levels range from higher cortical areas involved in planning and decision-making to lower spinal cord reflexes that respond automatically to external stimuli.
2.9K
Spinal Cord
527
The spinal cord, a critical component of the central nervous system, extends from the base of the brainstem to the lumbar region of the vertebral column. It is essential for maintaining physical stability and facilitating communication between the brain and peripheral parts of the body.
527
Spinal Cord: Information Processing
1.4K
The spinal cord is an integral hub for motor and sensory information that enables the brain to communicate with the peripheral nervous system (PNS). This communication consists of relaying sensory data and transmission of motor commands.
Sensory Information Processing
Sensory information processing begins at the sensory receptors located in the skin and other tissues, which detect somatic sensory stimuli such as touch, temperature, or pain. These receptors function as catalysts, initiating...
Sensory Information Processing
Sensory information processing begins at the sensory receptors located in the skin and other tissues, which detect somatic sensory stimuli such as touch, temperature, or pain. These receptors function as catalysts, initiating...
1.4K


