两种基因组变异与HPV类型特异性宫癌风险的关联
Finja Seifert1, Rieke Eisenblätter1, Julia Beckmann1
1Gynaecology Research Unit, Comprehensive Cancer Center, Hannover Medical School, D-30625, Hannover, Germany.
Tumour virus research
|July 27, 2023
概括
与人类乳头瘤病毒 (HPV) 血清阳性相关的遗传变异可能会影响特定的宫癌风险. 一种变异,rs9357152,影响HLA-DRB1基因表达,可能影响HPV相关癌症的发展.
科学领域:
- 遗传学 遗传学 是一个
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 人类乳头瘤病毒 (HPV) 感染是侵袭性宫癌的主要原因.
- 以前的研究将特定的遗传变异 (rs9357152,rs4243652) 与HPV16/18病毒阳性联系起来.
- 这些变体与特定类型的宫癌的相关性仍然不清楚.
研究的目的:
- 调查HPV血清阳性变体 (rs9357152,rs4243652) 是否与特定类型的宫癌有关.
- 为了确定 rs9357152 变异是否影响宫组织中人类白细胞抗原 (HLA) 位点的基因表达.
主要方法:
- 进行了一项遗传病例控制研究,将宫癌病例分为HPV16或HPV18的分层.
- 评估了rs9357152和HPV16阳性癌症之间的关联.
- 评估了rs4243652和HPV18阳性腺癌之间的关联.
- 测试了rs9357152对256个宫组织中36个HLA基因的表达的影响.
主要成果:
- rs9357152与侵袭性HPV16阳性宫癌 (OR1.33,p=0.03) 有显著的关联.
- rs4243652与HPV18阳性腺癌 (OR2.96,p=0.02) 有关.
- rs9357152被确定为HPV阳性组织中HLA-DRB1的表达定量特征位置 (eQTL),风险等位素降低mRNA水平.
结论:
- 与HPV血清阳性相关的遗传变异可能会影响特定类型的宫癌风险.
- 变体rs9357152可能通过调节HPV存在时的HLA-DRB1表达来影响子宫癌风险.
- 由于多重测试考虑,建议在更大的研究中进一步验证.
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