在物质使用流行病期间,Serratia marcescens细菌病的发病率和死亡率
Ryan Bloom1, Kinna Thakarar2, Kristina E Rokas3
1Tufts University School of Medicine, Boston, MA, USA.
International journal of antimicrobial agents
|July 27, 2023
概括
对于注射药物使用者 (PWID) 患有Serratia marcescens细菌病的结局与非PWID相似. 尽管PWID年轻,并患上较少的并发病,但感染性内心炎的发病率更高.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 公共卫生 公共卫生
背景情况:
- 塞拉蒂亚马尔塞森斯是一种环境细菌,会引起各种感染.
- 历史上与注射毒品的人 (PWID) 相关,关于这一关联的文献有限.
- 这项研究比较了PWID和非PWID中的S. marcescens细菌病.
研究的目的:
- 为了比较PWID和非PWID之间的S. marcescens细菌病的治疗特征和临床结果.
- 为了识别并发症,感染类型和治疗策略的差异.
- 评估这些患者群体的长期死亡率.
主要方法:
- 在高等医疗中心从2013-2019年进行的回顾性队列研究.
- 纳入标准:年龄≥18岁,血培养结果为S. marcescens的阳性.
- 在PWID和非PWID之间比较人口统计,临床和结果数据.
主要成果:
- 发现了14种PWID (21%) 和53种非PWID (79%).
- 患有PWID的人更年轻 (中位数为32岁对67岁),病较少 (7%对34%).
- 在PWID中,感染性内心炎 (IE) 发病率较高 (48%对0%),并且接受了更多的组合抗菌疗法 (29%对2%).
- 12个月的全因死亡率是可比的 (21%在两组).
结论:
- 患有S. marcescens细菌病的PWID的长期结果与非PWID可比.
- PWID代表了一个年轻的队列,并发病率较少,但IE发病率较高.
- 临床医生应在PWID中保持对IE的高度怀疑,以S. marcescens的细菌血症呈现.
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