手术前的骨质疏松症是胃癌胃切除术患者死亡的危险因素
Shota Shimizu1, Tomoyuki Matsunaga2, Shohei Sawata2
1Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine, Yonago, Japan s.shimizu@tottori-u.ac.jp.
Anticancer research
|July 27, 2023
概括
手术前的骨质疏松症或低骨矿物质密度与接受手术的胃癌患者的生存结果较差有关. 这一发现强调了骨质疏松症是胃癌总体和疾病特异性生存的重要预后因素.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是指放射学
- 骨的新陈代谢 骨的新陈代谢
背景情况:
- 手术前的骨质疏松症 (骨矿物质密度低) 是消化道癌症的已知预后因素.
- 它对胃切除术后胃癌 (GC) 预后的具体影响尚未得到充分证实.
研究的目的:
- 研究经过胃切除术的胃腺癌患者手术前骨质疏松症的预后意义.
- 为了确定低骨矿物质密度是否预测这个患者队列的整体存活率 (OS) 和疾病特异性存活率 (DSS).
主要方法:
- 对251名经过治疗性手术的胃腺癌患者进行了回顾性分析.
- 使用手术前计算机断层扫描 (CT) 评估的骨矿物质密度 (BMD),通过测量T11脊椎体中的平均像素密度.
- 接收器操作特征 (ROC) 分析,以确定OS和DSS的最佳BMD切断点.
主要成果:
- 骨质疏松症显示了曲线下的高面积和OS和DSS的预测值.
- 多变量分析表明,与没有手术前骨质疏松症患者相比,手术前骨质疏松症患者的生存状况明显差 (HR=3.607,p<0.001) 和DSS (HR=2.797,p=0.03) .
结论:
- 术前骨质疏松症与胃癌胃切除术患者的整体存活率和疾病特异性存活率较低显著相关.
- 在手术前的CT检测中发现的低骨矿物质密度是胃癌患者的宝贵预后指标.
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