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结肠直肠癌微环境的简化和优化免疫评分

Hiroyuki Nakane¹, Tomoya Sudo², Akihiro Kawahara³

¹Department of Surgery, Kurume University School of Medicine, Kurume, Japan nakane_hiroyuki@kurume-u.ac.jp.

Anticancer research

|July 27, 2023

概括

简化免疫评分 (IS) 使用瘤周边免疫细胞评估,特别是FOXP3,改善了结直肠癌 (CRC) 患者的预后能力. 这种方法为瘤免疫微环境 (TIME) 提供了更容易获得的评估.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
病理学病理学病理学

背景情况:

免疫评分 (IS) 评估瘤的免疫微环境 (TIME),但需要专门的工具.
正式的IS分析是复杂的,需要特定的试剂和数字病理学软件.
简化IS (s-IS) 可以提高时间评估的可访问性.

研究的目的:

调查简化IS (s-IS) 是否可以通过修改免疫细胞评估位置来取代正式IS.
为了确定是否添加T细胞子集标记 s-IS 增强结直肠癌 (CRC) 的预后影响.

主要方法:

分析了82例CRC病例,使用CD3,CD8,CD45RO和FOXP3.3的免疫组织化学.
通过数字病理学评估瘤中心和周边的免疫细胞表达.
使用对标位和组合的对应指数比较预后意义.

主要成果:

在单变量分析中,CD3,CD8和FOXP3水平是显著的预后因素.
瘤周边的免疫细胞评估显示出比瘤中心更强大的预后能力.
在多变量分析中,修改的s-IS (包括FOXP3) 独立预测了无复发和整体存活率.

结论:

通过在瘤周围评估CD3和CD8T细胞,可以简化CRC的TIME评估.
将FOXP3评估纳入s-IS显著提高了其预后能力.
简化IS为CRC的预后评估提供了更容易访问和更强大的工具.

关键词:

福克斯p3p3 在线观看免疫学得分免疫学得分时间评估时间评价结肠直肠癌是什么意思

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The Tumor Microenvironment

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