免疫相关肺炎的六周口服普雷迪尼索隆治疗:单臂II期研究
Masato Karayama1,2, Naoki Inui2,3, Yusuke Inoue2
1Department of Chemotherapy, Hamamatsu University School of Medicine, Hamamatsu, Japan karayama@hama-med.ac.jp.
Journal for immunotherapy of cancer
|July 27, 2023
概括
这项研究表明,口服普雷迪尼索隆在免疫检查点抑制剂 (ICI) 后有效治疗免疫相关肺炎 (irP). 该疗法在癌症患者中显示出高的控制率和可控的副作用.
科学领域:
- 在瘤学瘤学.
- 肺部病理学 肺部病理学
- 免疫学 免疫学 免疫学
背景情况:
- 免疫检查点抑制剂 (ICI) 可以引起与免疫相关的肺炎 (irP).
- 没有前性试验评估了ICI治疗后的irP治疗.
研究的目的:
- 评估口服普得尼索隆在癌症患者治疗irP的疗效和安全性.
- 为了确定6周和12周的肺炎控制率.
主要方法:
- 一项单臂II期研究招募了57名癌症患者,其IRP等级≥2.
- 患者接受口服普雷迪尼索隆 (1毫克/公斤/天),逐渐减少6周.
- 肺炎控制被定义为CT扫描完全消失或部分改善.
主要成果:
- 在6周后观察到91.1%的肺炎控制率.
- 在12周,对照率为57.1%.
- 最常见的不良事件包括高血糖症;没有发生与治疗相关的死亡.
结论:
- 口服普雷迪尼索隆 (1毫克/公斤/天,在6周内逐渐减少) 显示了对irP的有希望的临床益处.
- 这种疗法为irP提供了一个潜在的治疗选择,具有可控的毒性.
- 这是第一个评估IRP治疗后ICI治疗的前性研究.
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