从含有甲尼达的生物活性内牙水泥中进行控制的药物输送
Gabriela Souza Balbinot1, Vicente Castelo Branco Leitune1, Kelly Cristina Zatta2
1Department of Dental Materials, School of Dentistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
概括
形成了米特罗尼达液体纳米囊 (MTZLNC) 并将其纳入酸水泥中,从而创建了有效的抗菌内牙材料. 在0.3mg/ml度表明持续的E. faecalis减少没有细胞毒性.
科学领域:
- 生物材料科学 生物材料科学
- 在牙科的纳米技术.
- 牙周内科医院 牙周内科医院 牙周内科医院
背景情况:
- 基于酸的水泥在内牙治疗中至关重要.
- 纳入抗菌剂对于预防持久性感染至关重要.
- 甲尼达是治疗内牙感染的关键抗生素.
研究的目的:
- 为了配制甲尼达液体纳米囊 (MTZLNC).
- 评估MTZLNC对基于酸的牙周内水泥的物理化学和生物特性的影响.
- 评估改性水泥的体外抗菌疗效和生物活性.
主要方法:
- MTZLNC悬浮被准备好并进行了表征.
- 酸水泥的配方有不同的MTZLNC度 (0.3和0.15毫克/毫升) 或蒸水 (控制).
- 评估的放射性,定位时间,流量,压力强度,pH值,矿物沉积,细胞毒性和对*Enterococcus faecalis*的抗菌活性.
主要成果:
- MTZLNCs成功地制定了148nm的中介直径和83.44%的负载效率.
- 有MTZLNCs的水泥表现出流量增加和强度降低,但保持了pH-性和矿物沉积.
- 立即和9个月后观察到*E. faecalis*显著减少 (2 log10),没有细胞毒性.
结论:
- MTZLNC配方可开发具有适当生物活性的抗菌酸盐水泥.
- 0.3 mg/ml MTZLNC度提供了有效和可持续的抗菌活性.
- 虽然机械强度降低了,但生物活性和抗微生物特性在内牙科应用中得到了增强.
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