骨肌肉和心力衰竭 - - 中央和外围疾病之间的关系是什么?
Benedikt Gasser1, Jonathan Wagner1, Raphael Schoch1
1Department of Sport, Exercise and Health, Division Sport and Exercise Medicine, Section Rehabilitative and Regenerative Sport Medicine, University of Basel, Grosse Allee 6, CH-4052 Basel, Switzerland.
概括
心力衰竭会影响骨肌肉,降低其强度和功能. 这种全身性疾病导致患者的运动能力下降和肌肉细胞适应能力受损.
科学领域:
- 心脏病学 心脏病学
- 运动生理学 运动生理学
- 骨肌肉生物学 骨肌肉生物学
背景情况:
- 心力衰竭越来越多地被认为是一种系统性疾病,影响心脏以外的多个器官.
- 骨肌肉功能障碍是心力衰竭中常见的并发症,对运动不耐受和生活质量下降作出了重大贡献.
研究的目的:
- 与健康个体相比,研究心力衰竭患者骨肌的功能和结构能力.
- 在心力衰竭中探索心脏功能和骨肌肉性能之间的关系.
主要方法:
- 追溯病例控制研究涉及64名男性和15名患有心力衰竭的女性,与来自COMPLETE队列的健康对照进行匹配.
- 综合性评估包括心肺运动测试 (V·O2峰值),力量测试 (例如,反运动跳跃,大腿中部拉动) 和人类测量测量.
主要成果:
- 与对照组相比,心力衰竭患者表现出明显较低的V̇O2峰值 (28.6%在男性中,24.6%在女性中).
- 在男性和女性心力衰竭患者中,骨肌肉量减少了3.7%.
- 观察到骨肌功能受损,特别是男性患者加速能力 (快速收缩能力).
结论:
- 在心力衰竭中,严重的心血管循环障碍与骨肌肉的功能和结构能力中等至低有关.
- 随着时间的推移,骨肌的输液减少可能导致细胞适应,降低快速收缩能力,并导致外周适应不良.
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