在帕金森病的自发发言过程中声音声学不稳定性
Kara M Smith1, Meaghan Demers-Peel2, Christina Manxhari3
1Department of Neurology, University of Massachusetts Chan Medical School, Worcester, Massachusetts; NeuroNexus Institute, University of Massachusetts Chan Medical School, Worcester, Massachusetts.
概括
帕金森病 (PD) 中的言语运动不稳定性显示出对说话任务的声学下降,但轻度认知障碍 (MCI) 状态不会显著改变这些下降. 语音声学可能会反映PD-MCI,告知监控工具.
科学领域:
- 神经学 神经学
- 语音语言病理学 语言病理学
- 生物医学工程 生物医学工程
背景情况:
- 帕金森病 (PD) 影响运动和认知功能,影响沟通.
- 发声不稳定性在PD中被注意到,但在发言过程中声学变化和认知的作用尚未完全理解.
研究的目的:
- 研究患有PD的个体在演讲任务期间的声音声学变化.
- 为了确定轻度认知障碍 (MCI) 状态是否影响这些声学下降.
主要方法:
- 在正常认知 (PD-NC) 和MCI (PD-MCI) 的PD患者 (n=44) 中,在第一个和最后一个发言之间比较了声学参数 (f0平均值,STSD,CPPS,LH).
- 在彩虹通道和饼干盗窃图片描述任务中录制的语音.
- 用于比较群体和任务类型之间的声学下降的T测试.
主要成果:
- 在两个任务中,声学参数 (平均f0,STSD,CPPS) 从第一个到最后一个发音都下降了.
- 在PD-NC和PD-MCI组之间,声学衰退的"程度"没有显著差异.
- 与PD-NC相比,PD-MCI组在图像描述过程中显示出总体较低的f0变化和较低的CPPS.
结论:
- 语音声学参数,如平均f0,STSD和CPPS可能表明PD-MCI状态在阅读和自发言语.
- 语音运动的不稳定性在短时间任务的语音声学中很明显,独立于认知状态.
- 这些发现有助于开发用于监测PD语言和认知功能的算法.
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