白质超强度在Lewy体疾病的认知障碍中:一个多中心研究
Jinghuan Gan1, Zhihong Shi2, Shuai Liu2
1Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
European journal of neurology
|July 27, 2023
概括
白质超强度 (WMHs) 在患有勒维体 (DLB) 痴呆症中更为普遍,并且与更糟糕的结果有关. 在认知障碍 - 勒维体病 (CI-LB) 中增加WMH负担与较差的认知,运动功能和神经精神症状相关.
科学领域:
- 神经学 神经学
- 神经成像是一种神经成像.
- 认知神经科学 认知神经科学
背景情况:
- 白质过强度 (WMHs) 是已确定的脑血管疾病标志物.
- WMH与认知能力下降和不同类型痴呆症的较差结果有关.
- 有限的研究存在于认知障碍-莱维体疾病 (CI-LB) 中的WMH.
研究的目的:
- 调查WMHs与CI-LB患者的临床表现之间的关联.
- 为了在不同的CI-LB亚型中比较WMH负担.
主要方法:
- 对929名患有DLB,PDD,MCI-LB和PD-MCI的患者进行了回顾性多中心队列研究.
- 使用法泽卡斯方法半量化WMHs.
- 通过多变量线性或逻辑回归分析的关联.
主要成果:
- 患有莱维体痴呆症 (DLB) 的患者比其他CI-LB组表现出更高的Fazekas得分.
- 在MCI-LB和PD-MCI中,WMH负担与运动缺陷 (UPDRS III,Hoehn-Yahn) 和神经精神症状 (NPI) 有正相关.
- 在DLB和PDD中,WMH与运动分数,认知功能 (MoCA) 和没有REM睡眠行为障碍相关.
结论:
- 与其他CI-LB亚型相比,DLB显示出更高的WMH负担.
- 在CI-LB中,较大的WMH负担与认知能力受损,运动功能下降和神经精神病症状严重程度增加有显著联系.
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