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根据2021年世卫组织分类系统,扩散性质瘤的成像与病理生存分层
So Jeong Lee1, Ji Eun Park2, Seo Young Park3
1Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Korean journal of radiology
|July 27, 2023
概括
扩散性质瘤的基于成像的生存分层显示出与基于病理学的方法相似的性能,特别是预测无进展生存 (PFS). 这证实了2021年世卫组织对临床使用在质瘤管理中的分类.
科学领域:
- 神经瘤学神经瘤学
- 放射学 放射学是一门学科.
- 病理学 病理学 病理学
背景情况:
- 对扩散性质瘤患者的精确生存分层对于有效管理至关重要.
- 2021年世界卫生组织 (WHO) 的分类要求对其基于成像的生存分层方法进行临床验证.
研究的目的:
- 为了比较综合成像和基于病理学的方法在扩散性质瘤患者的生存分层的疗效.
- 评估2021年世卫组织分类基于成像的风险分层的表现.
主要方法:
- 来自癌症基因组图谱 (141名患者) 和阿桑医疗中心 (131名患者) 的扩散性质瘤病例分析.
- 神经放射学家将质瘤分为五个基于成像的风险子组和三个风险组,这些风险组基于2021年世界卫生组织使用CT和MRI的分类.
- 无进展生存期 (PFS) 和整体生存期 (OS) 估计并使用受体操作特征 (AUC) 分析下的时间依赖区域进行比较.
主要成果:
- 无论是OS还是PFS,都按基于成像的风险子组和组显著分层 (P < 0.001).
- 基于成像的组在预测1年 (AUC,0.787) 和5年PFS (AUC,0.823) 中表现高,与基于病理学的预测相比.
- 结合临床预测因素,基于成像的模型在1年和3年的PFS中实现了与基于病理的模型相似的性能.
结论:
- 使用2021年世卫组织分类的基于成像的生存分层显示了与基于病理学的方法相似的性能.
- 这种成像方法对于预测扩散性质瘤的无进展生存特别有效.
- 这些发现支持2021年世卫组织对质瘤管理的分类的临床实用性.
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