海马集团的动态和记忆性能在编码过程中通过呼吸来调节
Nozomu H Nakamura1, Hidemasa Furue2, Kenta Kobayashi3
1Division of Physiome, Department of Physiology, Hyogo Medical University, 1-1, Mukogawa cho, Nishinomiya, Hyogo, 663-8501, Japan. no-nakamura@hyo-med.ac.jp.
呼吸会影响记忆编码. 在学习过程中控制呼吸会损害小鼠的物体检测和恐惧记忆,显示出呼吸.
科学领域:
- 神经科学是一个神经科学.
- 呼吸系统生理学 呼吸系统生理学
- 记忆研究 记忆研究
背景情况:
- 呼吸协调海马活动在线状态下像睡眠.
- 呼吸在线记忆编码中的作用尚不清楚.
研究的目的:
- 调查呼吸在线记忆编码中的作用.
- 为了确定呼吸活动是否会影响记忆形成期间的海马体动态.
主要方法:
- 在小鼠中使用光遗传学操纵来控制PreBötzinger复合体 (PreBötC),大脑的呼吸节律发生器.
- 在对象探索和恐惧调节任务期间诱导间歇性呼吸暂停 (呼吸停止).
- 记录了海马体CA3细胞组合的变化.
主要成果:
- 在对象探索期间间歇性PreBötC诱导的呼吸暂停损害了新型对象的检测.
- 在恐惧记忆编码期间的呼吸暂停阻止了对有条件刺激 (CS +) 的反应结行为.
- 呼吸暂停阻碍了海马CA3细胞组合的动态变化,通常与CS+刺激一起观察到.
结论:
- 在线记忆编码期间,包括呼吸频率在内的中央呼吸活动被招募.
- 呼吸动态在学习过程中显著塑造海马群活动和记忆表现.
- 这些发现突出了呼吸控制和认知过程之间的新联系.
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