通过多模式白质成像,增强的碳酸应激与精神分裂症中明显轴突密度下降之间的关联
Shuraku Son1, Makoto Arai2, Kazuya Toriumi2
1Department of Psychiatry, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawaharacho, Sakyo-Ku, Kyoto, 606-8507, Japan.
Scientific reports
|July 27, 2023
概括
增强的碳酸压力与精神分裂症中的轴突损伤有关. 高西丁水平与患者的细胞内体积分数 (ICVF) 降低相关,这表明氧化应激和白质异常之间存在联系.
科学领域:
- 神经科学是一个神经科学.
- 生物化学 生物化学
- 精神病学是一个精神病学.
背景情况:
- 碳烯应激,以反应性碳烯化合物为特征,有助于先进的糖化最终产品的形成.
- 之前的研究表明,在精神分裂症中,高碳酸压力和破坏白质完整性之间存在联系.
- 受这种压力影响的特定微观结构组件仍然不清楚.
研究的目的:
- 调查碳基压力标志物与精神分裂症中白质微观结构完整性之间的关联.
- 在精神分裂症患者中,鉴定碳酸压力破坏的特定白质成分.
主要方法:
- 招募了32名精神分裂症患者 (SCZ) 和45名健康对照 (HC).
- 采集的血液样本用于测量碳烯压力标记物:血托西丁和血清氧化.
- 使用多模态磁共振成像 (MRI) 来评估白质微结构:细胞内体积分数 (ICVF),方向分散指数 (ODI) 和自由水 (FW).
主要成果:
- SCZ患者表现出显著增加的血pentosidine水平.
- 白质分析显示,与HC相比,SCZ中平均ICVF下降,FW增加.
- 在SCZ中,血托西丁与平均ICVF之间发现了负相关性.
- 在血清pyridoxal和HC中的平均ODI之间观察到负相关性.
结论:
- 增强的碳酸压力与精神分裂症中的轴突异常有关.
- 增加的托西丁水平与精神分裂症的轴突密度 (ICVF) 降低相关.
- 皮里多克萨尔水平与健康个体的白质定向 (ODI) 相相关.
相关概念视频
01:29Biological Causes of Schizophrenia
103
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
103
01:29Psychological and Sociocultural Causes of Schizophrenia
139
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
139
01:27Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
749
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
749