饮食中的多醇驱动剂量依赖的行为和分子变化,以重复的吗啡
Aya Osman1,2,3, Rebecca S Hofford1,3,4, Katherine R Meckel3,5
1Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Scientific reports
|July 27, 2023
概括
生物活性饮食多显示出对阿片类药物使用障碍 (OUD) 弹性有前途. 这项研究发现,多醇对小鼠的吗啡反应具有剂量依赖的影响,影响行为和肠道微生物群.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 微生物组研究 微生物组研究
背景情况:
- 阿片类药物使用障碍 (OUD) 带来了重大的健康挑战,目前的治疗方法往往是无效的或耐受性差.
- 迫切需要新的干预措施来增强对OUD的抵抗力.
- 生物活性饮食多制剂 (BDPP) 在各种神经精神疾病中显示出促进性和神经可塑性的潜力.
研究的目的:
- 在小鼠模型中研究BDPP对对吗啡的行为和分子反应的影响.
- 探索多醇对吗啡诱导的行为和神经生物学变化的剂量依赖影响.
- 研究BDPP对肠道微生物群的影响及其在调解多效应中的潜在作用.
主要方法:
- 在重复服用吗啡之前,雄性小鼠先用BDPP进行预治疗.
- 行为评估包括运动运动敏感性和有条件的位置偏好.
- 研究了核突的转录基因分析,微生物组合分析和SIRT1脱乙酶的参与.
主要成果:
- 在BDPP前期治疗后,显著改变了运动器官敏感性,并以剂量依赖的方式对位置偏好进行了条件化.
- 聚醇治疗减少了对低剂量吗啡 (5毫克/公斤) 的偏好,但在高剂量 (15毫克/公斤) 时增强了偏好.
- 转录基因分析揭示了核中的剂量×多相互作用,BDPP显著改变了微生物组的组成和功能.
结论:
- 生物活性饮食多对吗啡的行为和生理反应产生强大的,剂量依赖的影响.
- 聚醇与微生物群相互作用,影响对阿片类药物的反应.
- 这些发现为开发用于OUD弹性多基干预措施提供了基础.
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