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Updated: Jul 21, 2025

Chromosome Replicating Timing Combined with Fluorescent In situ Hybridization
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凝聚素保持复制时间,以抑制癌症基因上的DNA损伤

Jinchun Wu1, Yang Liu1, Zhengrong Zhangding1

  • 1The MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Center for Life Sciences, Genome Editing Research Center, Peking University, Beijing, China.

Nature genetics
|July 27, 2023
PubMed
概括

凝聚素损失,特别是RAD21枯竭,通过通过过度DNA复制启动诱导复制应激,导致全基因组DNA断裂和转位,可能促进癌症.

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