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Updated: Jul 21, 2025

Wild-type Blocking PCR Combined with Direct Sequencing as a Highly Sensitive Method for Detection of Low-Frequency Somatic Mutations
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在临床样本中检测低频突变,通过切除野生类型序列来增加突变丰度

Wei Chen1, Haiqi Xu1, Shenbin Dai1

  • 1Beijing National Laboratory for Molecular Sciences and MOE Key Laboratory of Bioorganic Chemistry and Molecular Engineering, College of Chemistry and Molecular Engineering, Peking University, Beijing, China.

Nature biomedical engineering
|July 27, 2023
PubMed
概括

一种新的DNA切除方法有效地检测基因组和无细胞DNA中的低频突变. 这项技术增强了突变DNA检测,改善了癌症诊断和研究.

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相关概念视频

Mutations in Microorganisms01:18

Mutations in Microorganisms

Mutations are heritable changes in an organism’s genome involving alterations in the base sequence of DNA or RNA. These changes can influence cellular processes and phenotypic traits, potentially transforming the unaltered wild type into a mutant form. Such changes, termed forward mutations, are pivotal in shaping the genetic diversity of organisms.RNA viruses exhibit the highest mutation rates due to the absence of robust proofreading mechanisms during genome replication. In contrast,...
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