基因组广泛关联研究的跨祖先元分析抑制控制的抑制控制研究
Aurina Arnatkeviciute1, Mathieu Lemire2, Claire Morrison3,4
1The Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Melbourne, VIC, Australia.
Molecular psychiatry
|July 27, 2023
概括
这项研究探讨了抑制控制的遗传基础,使用了一项大型的跨祖先基因组广泛关联研究. 虽然没有发现全基因组显著的关联,但观察到显著的遗传性,这表明对抑制控制的遗传影响.
科学领域:
- 神经科学是一个神经科学.
- 行为遗传学 行为遗传学
- 精神病学遗传学 精神病学遗传学
背景情况:
- 执行功能,特别是抑制控制,对于日常运作至关重要,并且与精神疾病有关.
- 抑制控制背后的遗传结构在很大程度上是未知的,这阻碍了其作为精神疾病的内分类型的使用.
研究的目的:
- 在一般人群中调查与抑制控制相关的常见遗传变异.
- 评估抑制性控制措施作为神经精神疾病的内类型的潜力.
主要方法:
- 进行了第一个跨祖先全基因组关联研究 (GWAS) 关于抑制控制特征 (GoRT,GoRT SD,SSRT) 使用来自四个祖先的14877人的数据.
- 分析了SNP遗传性和多基因风险与ADHD和精神分裂症的关联.
主要成果:
- 对于GoRT,GoRT SD或SSRT,没有发现全基因组显著的关联.
- GoRT SD和SSRT表现出显著的SNP遗传性 (8.2%),表明遗传影响.
- 对ADHD的多基因风险与欧洲人的GoRTSD有关;精神分裂症风险与欧洲人的GoRT和东亚人的SSRT有关.
结论:
- 常见的遗传变异影响抑制控制,显著的遗传性证明了这一点.
- 执行功能的测量显示出作为神经精神疾病的内类型的潜力.
- 需要更大的样本大小来确定抑制性控制特征的特定遗传关联.
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