嗅觉化学传感通过TGF-β信号和UPR激活来延长寿命
Evandro A De-Souza1, Maximillian A Thompson2, Rebecca C Taylor3,4
1Neurobiology Division, Medical Research Council Laboratory of Molecular Biology, Cambridge, UK. desouza.evs92@gmail.com.
Nature aging
|July 27, 2023
概括
病原体的气味会激活C. elegans的神经元未折叠蛋白反应 (UPRER),通过TGF-β信号传递增长寿命和蛋白质清除. 这重新连接了生物体的蛋白质稳定,证明了气味诱导的应激反应和寿命.
科学领域:
- 神经生物学 神经生物学 神经生物学
- 分子生物学分子生物学
- 老年学是一门学科.
背景情况:
- 动物使用化学感知线索在富含病原体的环境中生存.
- 病原性细菌会触发C. elegans的厌恶行为和分子防御.
- 神经元协调整个生物体对病原体感知的防御反应.
研究的目的:
- 调查病原体相关化合物的化学感应如何影响整个生物体的防御反应.
- 确定神经元信号在激活外围组织中的分子防御中的作用.
- 探索气味感知,压力反应和寿命之间的联系.
主要方法:
- 对C. elegans暴露于与病原体相关的挥发性化合物.
- 通过神经元中的xbp-1拼接来激活内质网膜展开蛋白质响应 (UPRER).
- 调查DAF-7/转化生长因子β (TGF-β) 信号的依赖性.
- 利用基因救援实验,包括在特定内神经元中DAF-1 TGF-β受体的救援.
主要成果:
- 挥发性病原体化合物诱导UPRER在外围组织中的激活,这取决于神经元xbp-1拼接.
- 香料诱导的UPRER激活依赖于DAF-7/TGF-β信号传递.
- 这种反应延长了寿命,并增强了有毒蛋白质的清除.
- 在RIM/RIC内部神经元中DAF-1的救援在特定气味暴露时恢复了UPRER激活.
结论:
- 细胞非自主UPRER在对病原体检测的反应中重新连接生物体的蛋白质稳定性.
- 气味的化学传感可以预先预防蛋白质毒性压力.
- 嗅觉感知为操纵压力反应和寿命提供了一个潜在的途径.
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