人类免疫缺陷病毒感染个体的粘菌菌病:对病例报告的系统审查
Valliappan Muthu1, Ritesh Agarwal2, Sahajal Dhooria2
1Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. valliappa@gmail.com.
Mycopathologia
|July 27, 2023
概括
粘菌在人类免疫缺陷病毒 (HIV) 感染中很罕见. 这次审查发现艾滋病毒患者有或没有额外的危险因素,包括静脉注射药物使用者的不同表现和真菌物种.
科学领域:
- 传染性疾病 传染性疾病
- 菌类学 菌类学是指菌类学.
- 免疫学 免疫学 免疫学
背景情况:
- 粘菌是一种不常见的机会性感染.
- 它在感染人类免疫缺陷病毒 (HIV) 的人群中很少发生,通常与额外的易感因素有关.
- 不同风险概况的艾滋病毒患者中粘性菌的特定临床差异和病因因因子尚未明确定义.
研究的目的:
- 系统地审查和描述艾滋病毒感染个体的粘性菌病例.
- 为了比较艾滋病毒阳性人群中不同风险群体的粘膜菌的临床表现,致病因子和结果.
- 为了确定额外的风险因素或静脉注射药物使用 (IVDU) 是否会影响艾滋病毒患者的粘性肌病特征.
主要方法:
- 进行了一项系统性审查,以确定艾滋病毒感染患者的粘膜菌病例.
- 病例被分为三个组:具有额外风险因素的HIV,具有IVDU的HIV和没有其他确定的风险因素的HIV.
- 提取和分析了临床表现,致病因子 (Mucorales) 和死亡率的数据.
主要成果:
- 确定并分类了94例艾滋病毒和粘膜菌的病例.
- 静脉注射药物使用者 (IVDU) 主要出现脏和大脑粘膜瘤,不同于其他群体更常见的犀牛轨道粘膜瘤 (ROM).
- 里索普斯是最常见的Mucorales物种总体,但Lichtheimia在IVDU中更为常见. 总体死亡率为53%,在各组一致.
结论:
- 感染艾滋病毒个体的粘菌是罕见的,特别是在没有额外的危险因素或IVDU的人群中.
- 艾滋病毒感染患者与其他风险因素或没有额外风险的人之间,临床表现和占主导地位的真菌属有所不同.
- 尽管表现和致病因子各异,但艾滋病毒患者的粘膜菌病死亡率仍然很高,并且没有受到额外风险因素或IVDU存在的显著影响.
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