在服用口服避孕药时获得的SERPINC1/抗素缺乏症:一个病例报告
D Denora1, M V Di Rosa2, N Altamura2
1Department of Medical Surgical Ad Health Science, Clinica Medica, Cattinara Hospital, University of Trieste, Trieste, Italy. donatella.denora@libero.it.
Journal of medical case reports
|July 27, 2023
概括
含有雌激素衍生物的口服避孕药可以降低SERPINC1水平,增加血栓形成的风险. 停止使用这些避孕药使患者的SERPINC1水平正常化,突出了对荷尔蒙疗法的个体敏感性.
科学领域:
- 生物化学 生物化学
- 血液学 血液学 血液学
- 药理学 药理学是指药理学的学科.
背景情况:
- SERPINC1是一个关键的糖蛋白调节血液凝结.
- 生产或获得的SERPINC1缺陷是血栓塞栓性疾病的重要危险因素.
- 获得的SERPINC1缺陷很少见,但与L-asparaginase治疗或口服避孕药使用等条件相关,通常被忽视.
研究的目的:
- 调查使用口服避孕药的患者SERPINC1水平降低的原因.
- 确定口服避孕药使用与SERPINC1缺陷之间的关系.
- 评估SERPINC1降低在避孕药停用后的可逆性.
主要方法:
- 一个50岁妇女的病例介绍,SERPINC1降低 (74%),D-二次数升高和同类蛋白.
- 进行了血栓友测试,以确定 SERPINC1 减少的潜在触发因素.
- 鉴定出gestodene 75 μg/ethinylestradiol 20 μg口服避孕药的使用是可能的原因.
主要成果:
- 在停止服用口服避孕药两个月后,SERPINC1水平恢复正常 (92%).
- 停药后的D-二聚体和同氨酸水平也恢复正常.
- 这表明特定的口服避孕药和SERPINC1减少之间存在直接联系.
结论:
- 个体患者对口服避孕药的敏感性有很大差异.
- 抗凝蛋白的遗传或表观遗传调节可能会影响对血栓事件的易感性.
- 荷尔蒙避孕药可以影响抗凝蛋白水平,需要对易受感染的个体进行仔细监测.
相关概念视频
Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants
1.2K
Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
1.2K
Anticoagulant Drugs: Low-Molecular-Weight Heparins
755
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
755
Disorders of Hemostasis
992
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
992
Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors
563
Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
563
Venous Thrombosis III: Interprofessional Care
10
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
10
Venous Thrombosis I: Introduction
13
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
13


