来自多种OMIC数据的全癌症分析揭示了AAMP作为不利的预后标志物
Yang Wang1, Ting Liu2, Ke Zhang1
1Department of General Surgical Department, Beijing Ditan Hospital, Capital Medical University, No. 8 Jing Shun East Street, Chaoyang District, Beijing, 100015, People's Republic of China.
European journal of medical research
|July 27, 2023
概括
血管相关迁移细胞蛋白 (AAMP) 在大多数癌症中过度表达,并与生存率低下有关. 高AAMP表达表明预后更差,特别是在肝肝细胞癌 (LIHC) 中,这表明其作为诊断和预后生物标志物的潜力.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 基因组学就是基因组学.
背景情况:
- 血管相关迁移细胞蛋白 (AAMP) 参与细胞迁移和癌症进展.
- AAMP的精确分子机制和泛癌相关性在很大程度上是未知的.
研究的目的:
- 调查AAMP的泛癌表达,改变和预后意义.
- 探索AAMP在肝肝细胞癌 (LIHC) 中的作用及其与临床特征和免疫微环境的相关性.
主要方法:
- 利用来自TIMER,TCGA,GTEx,CPTAC,HPA和cBioPortal的多组数据进行胰腺癌分析.
- 采用单变量和多变量考克斯回归,卡普兰-梅尔分析和斯皮尔曼相关性.
- 进行基因组丰富分析 (GSEA) 用于LIHC的功能探索.
主要成果:
- 在大多数癌症中,AAMP过度表达,与较差的整体存活率,疾病特异性存活率和LIHC和上腺皮质癌 (ACC) 的无进展间隔相关.
- 在几种癌症类型中,AAMP与瘤突变负担 (TMB) 和微卫星不稳定性 (MSI) 有显著的相关性.
- 在LIHC中,AAMP过度表达与先进的组织学级和病理阶段有关,作为一个独立的不良预后标志物,与免疫细胞透和检查点相关联.
结论:
- AAMP作为潜在的泛癌预后指标.
- 作为一种诊断和预后生物标志物,AAMP具有显著的潜力,特别是在LIHC.
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