男人,丸激素和Covid-19的关系
Kristina Groti Antonic1,2, Blaz Antonic3, Monica Caliber4
1Department of Endocrinology, Diabetes and Metabolic Diseases, University Medical Center Ljubljana, Ljubljana, Slovenia.
Clinical endocrinology
|July 28, 2023
概括
患有COVID-19 (冠状病毒疾病2019) 的男性丸激素水平较低不会使结果恶化. 相反,低丸激素是疾病的结果,而先前存在的阴性双胞胎症是住院治疗的危险因素.
科学领域:
- 内分泌学 在内分泌学.
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
背景情况:
- 男人比女性更严重地患有2019年新冠病毒病 (COVID-19) 和更高的死亡率.
- 最初的理论表明,丸激素促进了SARS-CoV-2感染和COVID-19的严重程度,但临床数据缺乏.
研究的目的:
- 审查雄激素在SARS-CoV-2感染和COVID-19严重性中的作用.
- 为了检查COVID-19对男性生殖健康和水平的影响.
主要方法:
- 在急性COVID-19期间对丸激素水平的临床研究的审查.
- 对研究COVID-19的雄激素调节疗法的临床试验的分析.
- 检查了对雄激素和SARS-CoV-2的临床前和机械学研究.
- 关于COVID-19对男性生殖健康的长期影响的文献评论.
主要成果:
- 患有COVID-19的男性血清丸激素度与炎症性细胞因子和疾病严重程度相反.
- 较低的丸激素水平似乎是影响下丘脑-垂体-丸轴的急性疾病的结果.
- 阻断雄激素信号的临床试验没有改善COVID-19的结果.
- 现有的男性阴性腺体缺陷症是COVID-19住院治疗的危险因素.
结论:
- 水平不会在男性中导致严重的COVID-19结果;低水平可能是疾病的结果.
- 虽然COVID-19可以透到丸,并可能导致炎,但其对男性阴性腺瘤发病率的长期影响尚不清楚.
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