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细菌合成可降解的特兰胺酸功能化的短纤维,用于抑制隐形出血

Luhan Bao¹, Zhiqiang Zhang¹, Xiaoxiao Li¹

¹Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025, P. R. China.

Small (Weinheim an der Bergstrasse, Germany)

|July 28, 2023

概括

这项研究引入了基于细菌纳米纤维素的新型血液静止材料 (OBNC-TXA),可以有效地阻止内部出血. 这些材料促进血液快速凝固和血红蛋白恢复,为创伤和手术护理提供了有前途的解决方案.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
血液静止研究血液静止研究

背景情况:

目前的静血剂主要针对可见的外部出血.
创伤后或手术后的隐形内出血导致严重的血红蛋白下降,贫血和死亡.
对于有效管理内部出血的先进材料有着至关重要的需求.

研究的目的:

开发和评估一种能够抑制隐形出血的新型静血材料.
为了合成可降解的纳米尺度短纤维从细菌纳米纤维素与tranexamic acid (OBNC-TXA) 接种.
为了评估OBNC-TXA在体外和体外模型中的静血效果.

主要方法:

细菌纳米纤维素 (BNC) 被氧化并与酸接种,形成OBNC-TXA纳米尺度短纤维.
这种材料被制成各种形式,包括乳液,凝,粉末和海绵.
试验室凝血试验和体内动物模型 (老鼠尾巴截肢,肝损伤,肌肉缺陷) 用于评估静血性能.

主要成果:

在实验室中,OBNC-TXA表现出明显优异的促凝性质,促进了血液细胞的快速聚合.
在体内研究表明,OBNC-TXA海绵在老鼠模型中有效减少出血.
该材料在直腹肌缺陷模型中成功抑制了隐形出血,在4天内,血红蛋白从128±5.5到165±2.6克L-1迅速恢复.

结论:

来自细菌纳米纤维素 (OBNC-TXA) 的可降解纳米尺度短纤维有效控制无形出血.
由于其可适应的形式,开发的材料显示出各种临床应用的潜力.
在管理内部出血方面,OBNC-TXA代表了显著的进步,通过恢复血红蛋白水平来改善患者的治疗结果.

关键词:

细菌纳米纤维素的细菌纳米纤维素血液静止血液静止血液静止看不见的出血隐形的出血特兰克萨姆酸是什么意思可见的出血明显的出血

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