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用于软骨组织工程的Zwitterionic颗粒状凝.

Maryam Asadikorayem1, František Surman1, Patrick Weber1

  • 1Tissue Engineering + Biofabrication Laboratory, Department of Health Sciences and Technology, ETH Zürich, Otto-Stern-Weg 7, Zürich, 8093, Switzerland.

Advanced healthcare materials
|July 28, 2023
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概括
此摘要是机器生成的。

可注射的zwitterionic颗粒状水凝被开发用于软骨组织工程. 这些生物相容的水凝支持状细胞的活力,增殖和细胞外基质的产生,为软骨再生提供了一个有前途的战略.

关键词:
卡尔博克西贝他因烯胺软骨 软骨类 软骨类它是颗粒状的颗粒.这种水凝是水凝.可以注射的水凝.微凝是一种微凝.这种水凝是zwitterionic水凝.

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科学领域:

  • 生物材料科学 生物材料科学
  • 组织工程是组织工程.
  • 再生医学是一种再生医学.

背景情况:

  • 兹威特基凝为软骨组织工程提供了卓越的生物相容性和防性质.
  • 目前的局限性包括缺乏用于细胞封装的注射配方.

研究的目的:

  • 为软骨组织工程开发可注射,自我愈合和在现场交叉链接的zwitterionic颗粒状水凝.
  • 评估这些水凝的生物相容性和有效性,用于状细胞封装和软骨矩阵形成.

主要方法:

  • 通过机械碎片化散装水凝 (CBAA或CBAA/SBMA) 制造齐特里昂颗粒状水凝.
  • 酵素交叉连接使用胡卜过氧化酶进行结构稳定.
  • 在水凝系统内封装和培养人类初级红细胞.

主要成果:

  • 开发的颗粒状水凝可注射,自我愈合,并且可以通过酶交叉链接,形成微孔结构.
  • 封装的冠状细胞表现出高活力,增殖,迁移和软骨细胞外基质 (ECM) 的产生.
  • 增加的水凝多孔性和SBMA结合增强了细胞增殖和ECM分泌.

结论:

  • 这种新的策略提供了一种简单,可扩展的方法,可以使用zwitterionic颗粒状水凝来设计软骨.
  • 这些水凝的可注射和生物相容性促进了直接的细胞封装,并促进了体生成.
  • 这些发现突显了zwitterionic颗粒状水凝在各种组织工程应用中的潜力.